Docetaxel






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1 7473877 Expression of the nerve growth factor gene is controlled by the microtubule network. J Neurosci Res 1995 Jul 1 1
2 7833145 Effects of the microtubule-disturbing agents docetaxel (Taxotere), vinblastine and vincristine on epidermal growth factor-receptor binding of human breast cancer cell lines in vitro. Eur J Cancer 1994 2
3 7896535 Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro. Invest New Drugs 1994 1
4 7914541 Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel). J Med Chem 1994 Aug 5 4
5 7915328 Structure-activity studies of antitumor taxanes: synthesis of novel C-13 side chain homologated taxol and taxotere analogs. J Med Chem 1994 Sep 2 1
6 7945455 Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol 1994 Oct 7 2
7 7959286 Comparative studies of taxol and taxotere on tumor growth and lymphocyte functions. Gynecol Oncol 1994 Nov 1
8 8100632 Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm Res 1993 May 1
9 8548776 Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. Cancer Res 1996 Jan 1 5
10 8604451 Preclinical profile of docetaxel (taxotere): efficacy as a single agent and in combination. Semin Oncol 1995 Dec 1
11 8640817 Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans. Cancer Res 1996 Mar 15 3
12 9000560 Bcl2 is the guardian of microtubule integrity. Cancer Res 1997 Jan 15 2
13 9062409 In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin. Br J Cancer 1997 1
14 9062411 Synergistic antiproliferative activity of tamoxifen and docetaxel on three oestrogen receptor-negative cancer cell lines is mediated by the induction of apoptosis. Br J Cancer 1997 3
15 9066624 Docetaxel enhances the expression of E-cadherin and carcinoembryonic antigen (CEA) on human colon cancer cell lines in vitro. Anticancer Res 1997 Jan-Feb 11
16 9070886 Pretreatment by tubulin agents decreases C-MYC induction in human colon carcinoma cell line HT29-D4. Biochem Biophys Res Commun 1997 Feb 24 3
17 9180834 Biotransformation of taxoids by human cytochromes P450: structure-activity relationship. Bull Cancer 1997 Feb 2
18 9285690 Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A. Oncogene 1997 Aug 18 2
19 9288793 Paclitaxel- and docetaxel-dependent activation of CA-125 expression in human ovarian carcinoma cells. Cancer Res 1997 Sep 1 2
20 9322876 Pharmacology of the taxanes. Pharmacotherapy 1997 Sep-Oct 4
21 9364542 Docetaxel in combination with platinums in patients with advanced non-small-cell lung cancer. Oncology (Williston Park) 1997 Aug 3
22 9478937 Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem 1998 Feb 27 4
23 9496387 Comparative antitumor efficacy of docetaxel and paclitaxel in nude mice bearing human tumor xenografts that overexpress the multidrug resistance protein (MRP) Ann Oncol 1997 Dec 7
24 9499461 Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro. Int J Oncol 1998 Apr 15
25 9520464 Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci U S A 1998 Mar 31 2
26 9523735 Identification of the structural region of taxol that may be responsible for cytokine gene induction and cytotoxicity in human ovarian cancer cells. Cancer Chemother Pharmacol 1998 3
27 9551718 Necessity of interleukin-1beta converting enzyme cascade in taxotere-initiated death signaling. Eur J Pharmacol 1998 Feb 5 4
28 9571974 [Breast cancer with liver metastasis responsive to docetaxel: case report]. Gan To Kagaku Ryoho 1998 Apr 1
29 9572489 Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol. Oncogene 1998 Apr 23 2
30 9602269 First-line treatment of advanced non-small-cell lung cancer with docetaxel and cisplatin: a multicenter phase II study. Ann Oncol 1998 Mar 1
31 9621410 Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position. Chem Pharm Bull (Tokyo) 1998 May 1
32 9703875 Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells. Anticancer Res 1998 Jul-Aug 3
33 9731500 Docetaxel chronopharmacology in mice. Cancer Res 1998 Sep 1 4
34 9750029 Preclinical approach for identifying drug interactions. Cancer Chemother Pharmacol 1998 1
35 9825831 Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver. Pharmacogenetics 1998 Oct 6
36 9864431 The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep 1999 Jan-Feb 3
37 9871592 Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs. Bioorg Med Chem Lett 1998 Mar 3 1
38 9886421 Effect of taxol and taxotere on gene expression in macrophages: induction of the prostaglandin H synthase-2 isoenzyme. J Immunol 1999 Jan 1 2
39 9923557 Docetaxel and granulocyte colony-stimulating factor in patients with advanced non-small-cell lung cancer previously treated with platinum-based chemotherapy: a multicenter phase II trial. Cancer Chemother Pharmacol 1999 1
40 9925734 Ab initio conformational study of the phenylisoserine side chain of paclitaxel. J Med Chem 1999 Jan 28 1
41 10092957 Clinical pharmacokinetics of docetaxel. Clin Pharmacokinet 1999 Feb 2
42 10213206 Phase I trial of docetaxel with filgrastim support in pediatric patients with refractory solid tumors: a collaborative Pediatric Oncology Branch, National Cancer Institute and Children's Cancer Group trial. Clin Cancer Res 1999 Apr 3
43 10226557 Effect of docetaxel with cisplatin or vinorelbine on lung cancer cell lines. Anticancer Res 1999 Jan-Feb 1
44 10226594 Nanomolar range docetaxel treatment sensitizes MCF-7 cells to chemotherapy induced apoptosis, induces G2M arrest and phosphorylates bcl-2. Anticancer Res 1999 Jan-Feb 3
45 10405003 Radiobiological effects of docetaxel (Taxotere): a potential radiation sensitizer. Int J Radiat Biol 1999 Jun 3
46 10405640 Cytoskeletons and antimitotic agents developed in Japan. Anticancer Drug Des 1999 Apr 1
47 10426457 Recent progress in the clinical development of docetaxel (Taxotere). Semin Oncol 1999 Jun 2
48 10470115 Introduction of gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis. Anticancer Res 1999 May-Jun 1
49 10493958 Activation and the interaction of proapoptotic genes in modulating sensitivity to anticancer drugs in gastric cancer cells. Int J Oncol 1999 Oct 1
50 10574245 Docetaxel and gemcitabine activity in NSCLC cell lines and in primary cultures from human lung cancer. Br J Cancer 1999 Oct 2