1 | 1731887 | Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene. | Biochemistry | 1992 Jan 14 |
2 |
2 | 2835006 | Methylene blue competes with paraquat for reduction by flavo-enzymes resulting in decreased superoxide production in the presence of heme proteins. | Arch Biochem Biophys | 1988 May 1 |
2 |
3 | 8674031 | Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. | Cancer Res | 1996 Jul 1 |
14 |
4 | 8895733 | Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. | Cancer Res | 1996 Nov 1 |
3 |
5 | 9280310 | Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein. | FEBS Lett | 1997 Aug 18 |
1 |
6 | 9373241 | The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. | Blood | 1997 Dec 1 |
4 |
7 | 9427698 | Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. | Blood | 1998 Jan 15 |
4 |
8 | 9639406 | Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells. | Int J Cancer | 1998 Jul 3 |
4 |
9 | 9748140 | UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner. | Clin Cancer Res | 1998 Sep |
1 |
10 | 9784425 | The p16(INK4A) protein and flavopiridol restore yeast cell growth inhibited by Cdk4. | Biochem Biophys Res Commun | 1998 Sep 29 |
4 |
11 | 9801360 | Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. | J Neurosci | 1998 Nov 15 |
2 |
12 | 9802881 | Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. | J Clin Invest | 1998 Nov 1 |
4 |
13 | 9808574 | Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. | Blood | 1998 Nov 15 |
8 |
14 | 9829756 | Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. | Clin Cancer Res | 1998 Nov |
3 |
15 | 10363974 | Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. | Cancer Res | 1999 Jun 1 |
2 |
16 | 10367753 | In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer. | Cancer Chemother Pharmacol | 1999 |
1 |
17 | 10375610 | Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line. | Int J Oncol | 1999 Jul |
1 |
18 | 10413104 | Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein. | FEBS Lett | 1999 Jul 2 |
5 |
19 | 10414953 | Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. | J Neurosci | 1999 Aug 1 |
1 |
20 | 10430095 | Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. | Clin Cancer Res | 1999 Jul |
3 |
21 | 10441105 | Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat. | Circulation | 1999 Aug 10 |
3 |
22 | 10454206 | Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target. | Pharmacol Ther | 1999 May-Jun |
1 |
23 | 10493518 | Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. | Cancer Res | 1999 Sep 15 |
10 |
24 | 10496352 | Potent interaction of flavopiridol with MRP1. | Br J Cancer | 1999 Sep |
6 |
25 | 10500810 | Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs. | Adv Exp Med Biol | 1999 |
1 |
26 | 10516294 | Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. | J Neurosci | 1999 Oct 15 |
1 |
27 | 10537334 | Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. | Clin Cancer Res | 1999 Oct |
8 |
28 | 10537362 | Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. | Clin Cancer Res | 1999 Oct |
4 |
29 | 10554012 | Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. | Cancer Res | 1999 Nov 1 |
7 |
30 | 10656453 | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | Clin Cancer Res | 2000 Jan |
9 |
31 | 10665481 | Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. | Invest New Drugs | 1999 |
1 |
32 | 10741717 | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | Clin Cancer Res | 2000 Mar |
3 |
33 | 10777774 | Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage. | J Neurosci | 2000 May 1 |
2 |
34 | 10811119 | Flavopiridol binds to duplex DNA. | Cancer Res | 2000 May 1 |
1 |
35 | 10851232 | Induction and modulation of cerebellar granule neuron death by E2F-1. | J Biol Chem | 2000 Aug 18 |
1 |
36 | 10884572 | Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression. | Neuropharmacology | 2000 Jul 24 |
1 |
37 | 10887097 | Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. | Blood | 2000 Jul 15 |
9 |
38 | 10896673 | Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release. | J Biol Chem | 2000 Oct 13 |
6 |
39 | 10924512 | Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. | J Biol Chem | 2000 Nov 3 |
1 |
40 | 10995888 | Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol. | Int J Oncol | 2000 Oct |
5 |
41 | 11052627 | Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. | Cancer Chemother Pharmacol | 2000 |
1 |
42 | 11060782 | Cyclin-dependent kinase inhibitors: novel anticancer agents. | Expert Opin Investig Drugs | 2000 Aug |
1 |
43 | 11063609 | Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. | J Med Chem | 2000 Nov 2 |
4 |
44 | 11093360 | Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. | Expert Opin Investig Drugs | 2000 Dec |
1 |
45 | 11205902 | Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. | Clin Cancer Res | 2001 Jan |
6 |
46 | 11311660 | Mechanisms of action of flavopiridol. | Crit Rev Oncol Hematol | 2001 May |
2 |
47 | 11326318 | Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. | Neoplasia | 2001 Jan-Feb |
1 |
48 | 11343231 | Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. | Hepatology | 2001 May |
2 |
49 | 11417480 | Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. | Leukemia | 2001 Jun |
1 |
50 | 11464216 | The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway. | Cell Death Differ | 2001 Jul |
2 |