alvocidib






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1 1731887 Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene. Biochemistry 1992 Jan 14 2
2 2835006 Methylene blue competes with paraquat for reduction by flavo-enzymes resulting in decreased superoxide production in the presence of heme proteins. Arch Biochem Biophys 1988 May 1 2
3 8674031 Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 1996 Jul 1 14
4 8895733 Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res 1996 Nov 1 3
5 9280310 Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein. FEBS Lett 1997 Aug 18 1
6 9373241 The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 1997 Dec 1 4
7 9427698 Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998 Jan 15 4
8 9639406 Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells. Int J Cancer 1998 Jul 3 4
9 9748140 UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner. Clin Cancer Res 1998 Sep 1
10 9784425 The p16(INK4A) protein and flavopiridol restore yeast cell growth inhibited by Cdk4. Biochem Biophys Res Commun 1998 Sep 29 4
11 9801360 Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. J Neurosci 1998 Nov 15 2
12 9802881 Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J Clin Invest 1998 Nov 1 4
13 9808574 Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood 1998 Nov 15 8
14 9829756 Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. Clin Cancer Res 1998 Nov 3
15 10363974 Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res 1999 Jun 1 2
16 10367753 In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer. Cancer Chemother Pharmacol 1999 1
17 10375610 Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line. Int J Oncol 1999 Jul 1
18 10413104 Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein. FEBS Lett 1999 Jul 2 5
19 10414953 Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. J Neurosci 1999 Aug 1 1
20 10430095 Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. Clin Cancer Res 1999 Jul 3
21 10441105 Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat. Circulation 1999 Aug 10 3
22 10454206 Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target. Pharmacol Ther 1999 May-Jun 1
23 10493518 Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res 1999 Sep 15 10
24 10496352 Potent interaction of flavopiridol with MRP1. Br J Cancer 1999 Sep 6
25 10500810 Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs. Adv Exp Med Biol 1999 1
26 10516294 Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci 1999 Oct 15 1
27 10537334 Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. Clin Cancer Res 1999 Oct 8
28 10537362 Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. Clin Cancer Res 1999 Oct 4
29 10554012 Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res 1999 Nov 1 7
30 10656453 Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. Clin Cancer Res 2000 Jan 9
31 10665481 Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest New Drugs 1999 1
32 10741717 Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. Clin Cancer Res 2000 Mar 3
33 10777774 Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage. J Neurosci 2000 May 1 2
34 10811119 Flavopiridol binds to duplex DNA. Cancer Res 2000 May 1 1
35 10851232 Induction and modulation of cerebellar granule neuron death by E2F-1. J Biol Chem 2000 Aug 18 1
36 10884572 Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression. Neuropharmacology 2000 Jul 24 1
37 10887097 Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 2000 Jul 15 9
38 10896673 Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release. J Biol Chem 2000 Oct 13 6
39 10924512 Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. J Biol Chem 2000 Nov 3 1
40 10995888 Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol. Int J Oncol 2000 Oct 5
41 11052627 Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. Cancer Chemother Pharmacol 2000 1
42 11060782 Cyclin-dependent kinase inhibitors: novel anticancer agents. Expert Opin Investig Drugs 2000 Aug 1
43 11063609 Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem 2000 Nov 2 4
44 11093360 Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. Expert Opin Investig Drugs 2000 Dec 1
45 11205902 Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. Clin Cancer Res 2001 Jan 6
46 11311660 Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol 2001 May 2
47 11326318 Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. Neoplasia 2001 Jan-Feb 1
48 11343231 Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. Hepatology 2001 May 2
49 11417480 Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. Leukemia 2001 Jun 1
50 11464216 The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway. Cell Death Differ 2001 Jul 2