Pub. Date : 1999 Feb
PMID : 9950818
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells. | Polyamines | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | The increased AP-1 complexes in polyamine-deficient cells were dramatically supershifted by the anti-JunD antibody but not by antibodies against c-Jun, JunB, or Fos proteins. | Polyamines | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | There were significant increases in JunD mRNA and protein in DFMO-treated cells, although expression of the c-fos, c-jun, and junB genes decreased. | Eflornithine | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | The increase in JunD/AP-1 activity in DFMO-treated cells was associated with a significant decrease in cell division. | Eflornithine | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1. | Polyamines | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1. | Eflornithine | JunD proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |