PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9950818-0	1999	Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells.	Polyamines	0-9	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-58	
9950818-0	1999	Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells.	Polyamines	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-63	
9950818-4	1999	The current study tests the hypothesis that polyamines influence cell growth by altering the balance of positive and negative Jun/AP-1 activities in intestinal epithelial cells.	Polyamines	44-54	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-134	
9950818-6	1999	Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor for polyamine synthesis, for 4 and 6 days completely depleted cellular polyamine levels, while AP-1 binding activity was significantly increased.	Eflornithine	18-47	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-176	
9950818-6	1999	Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor for polyamine synthesis, for 4 and 6 days completely depleted cellular polyamine levels, while AP-1 binding activity was significantly increased.	Eflornithine	49-53	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-176	
9950818-7	1999	Spermidine, when given together with DFMO, restored AP-1 binding activity toward normal.	Spermidine	0-10	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-56	
9950818-7	1999	Spermidine, when given together with DFMO, restored AP-1 binding activity toward normal.	Eflornithine	37-41	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-56	
9950818-8	1999	The increased AP-1 complexes in polyamine-deficient cells were dramatically supershifted by the anti-JunD antibody but not by antibodies against c-Jun, JunB, or Fos proteins.	Polyamines	32-41	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-18	
9950818-8	1999	The increased AP-1 complexes in polyamine-deficient cells were dramatically supershifted by the anti-JunD antibody but not by antibodies against c-Jun, JunB, or Fos proteins.	Polyamines	32-41	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	101-105	
9950818-9	1999	There were significant increases in JunD mRNA and protein in DFMO-treated cells, although expression of the c-fos, c-jun, and junB genes decreased.	Eflornithine	61-65	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-40	
9950818-9	1999	There were significant increases in JunD mRNA and protein in DFMO-treated cells, although expression of the c-fos, c-jun, and junB genes decreased.	Eflornithine	61-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	108-113	
9950818-9	1999	There were significant increases in JunD mRNA and protein in DFMO-treated cells, although expression of the c-fos, c-jun, and junB genes decreased.	Eflornithine	61-65	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-130	
9950818-10	1999	The increase in JunD/AP-1 activity in DFMO-treated cells was associated with a significant decrease in cell division.	Eflornithine	38-42	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-20	
9950818-10	1999	The increase in JunD/AP-1 activity in DFMO-treated cells was associated with a significant decrease in cell division.	Eflornithine	38-42	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-25	
9950818-12	1999	DFMO prevented the stimulation of c-Jun/AP-1 activity induced by 5% dialyzed serum.	Eflornithine	0-4	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-44	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Polyamines	31-40	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-89	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Polyamines	31-40	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	218-222	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Eflornithine	151-155	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-89	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Eflornithine	151-155	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-134	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Eflornithine	151-155	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	218-222	
9950818-13	1999	These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1.	Eflornithine	151-155	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-134	
9950818-14	1999	These findings suggest that polyamines regulate cell growth at least partially by modulating the balance of positive and negative Jun/AP-1 activities in the intestinal mucosa.	Polyamines	28-38	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	134-138