Title : Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.

Pub. Date : 1998 Nov 24

PMID : 9826659






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We demonstrate that expression of either wild-type PTP1B or the substrate-trapping mutant form of the enzyme (PTP1B-D181A) in p210 bcr-abl-transformed Rat-1 fibroblasts diminished the ability of these cells to form colonies in soft agar, to grow in reduced serum, and to form tumors in nude mice. Agar protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
2 We demonstrate that expression of either wild-type PTP1B or the substrate-trapping mutant form of the enzyme (PTP1B-D181A) in p210 bcr-abl-transformed Rat-1 fibroblasts diminished the ability of these cells to form colonies in soft agar, to grow in reduced serum, and to form tumors in nude mice. Agar protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus