Pub. Date : 1998 Oct 9
PMID : 9801165
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line. | leupeptin | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 2 | Murine N9 microglia accumulated A beta from media containing 0.67 microM A beta within 6 h. In N9 and in primary rat microglia, chloroquine, which disrupts lysosomal pH, increased A beta-induced accumulation of A beta, particularly A beta1-42. | Chloroquine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 3 | Murine N9 microglia accumulated A beta from media containing 0.67 microM A beta within 6 h. In N9 and in primary rat microglia, chloroquine, which disrupts lysosomal pH, increased A beta-induced accumulation of A beta, particularly A beta1-42. | Chloroquine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 4 | Leupeptin similarly enhanced A beta accumulation. | leupeptin | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 5 | After prolonged incubations, chloroquine enhanced A beta multimer (8-12 kDa) accumulation, an effect inhibited by fucoidan. | Chloroquine | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |