Title : The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.

Pub. Date : 1998 Nov

PMID : 9774651






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Caspase 3 activation, cytochrome c release, and apoptotic nuclear morphological changes were induced after onset of the MPT and were prevented by CsA. Cyclosporine caspase 3 Rattus norvegicus
2 In contrast, Asp-Glu-Val-Asp-cho, an inhibitor of caspase 3, did not block depolarization or onset of the MPT induced by TNFalpha, although it inhibited cell death completely. Asp-Glu-Val-Asp-CHO caspase 3 Rattus norvegicus