Title : Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor.

Pub. Date : 1998 Oct

PMID : 9763401






4 Functional Relationships(s)
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1 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens