Pub. Date : 1998 Sep
PMID : 9737720
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells. | Glucose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 2 | Glucose causes a coordinated transcriptional activation of the IEGs c-fos, c-jun, JunB, zif-268, and nur-77 in the pancreatic beta-cell line INS-1. | Glucose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 3 | The accumulation of c-fos, JunB, and nur-77 mRNA occurs at physiological concentrations of glucose (3 to 11 mM), requires a 1-2 h period, and is mimicked by other nutrient stimuli including mannose, leucine plus glutamine, and pyruvate. | Glucose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 4 | The accumulation of c-fos, JunB, and nur-77 mRNA occurs at physiological concentrations of glucose (3 to 11 mM), requires a 1-2 h period, and is mimicked by other nutrient stimuli including mannose, leucine plus glutamine, and pyruvate. | Mannose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 5 | The accumulation of c-fos, JunB, and nur-77 mRNA occurs at physiological concentrations of glucose (3 to 11 mM), requires a 1-2 h period, and is mimicked by other nutrient stimuli including mannose, leucine plus glutamine, and pyruvate. | Leucine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 6 | The accumulation of c-fos, JunB, and nur-77 mRNA occurs at physiological concentrations of glucose (3 to 11 mM), requires a 1-2 h period, and is mimicked by other nutrient stimuli including mannose, leucine plus glutamine, and pyruvate. | Glutamine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 7 | The accumulation of c-fos, JunB, and nur-77 mRNA occurs at physiological concentrations of glucose (3 to 11 mM), requires a 1-2 h period, and is mimicked by other nutrient stimuli including mannose, leucine plus glutamine, and pyruvate. | Pyruvic Acid | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 8 | A role for Ca2+ signaling is inferred, since the L-type Ca2+ channel blocker nifedipine markedly reduces the induction of c-fos and nur-77 by glucose and GLP-1. | Nifedipine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 9 | A role for Ca2+ signaling is inferred, since the L-type Ca2+ channel blocker nifedipine markedly reduces the induction of c-fos and nur-77 by glucose and GLP-1. | Glucose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 10 | The results indicate that GLP-1 and PACAP-38 act as competence factors for the action of glucose on c-fos, JunB, and nur-77. | Glucose | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |