Title : Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.

Pub. Date : 1998 Sep

PMID : 9733665






4 Functional Relationships(s)
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Protein Name
Organism
1 Incubation of methoxychlor with microsomes from insect cells overexpressing either CYP1A2, CYP2C18, or CYP2C19 yielded mono-OH-M with turnover numbers of 14.9, 15.5, and 39.1 nmol/min/nmol of P450, respectively. Methoxychlor cytochrome P450 family 2 subfamily C member 18 Homo sapiens
2 Incubation of methoxychlor with microsomes from insect cells overexpressing either CYP1A2, CYP2C18, or CYP2C19 yielded mono-OH-M with turnover numbers of 14.9, 15.5, and 39.1 nmol/min/nmol of P450, respectively. mono-oh-m cytochrome P450 family 2 subfamily C member 18 Homo sapiens
3 Incubations with purified CYP2C19 and CYP2C18 resulted in formation of mono-OH-M, and also the bis-demethylated metabolite. mono-oh-m cytochrome P450 family 2 subfamily C member 18 Homo sapiens
4 Although CYP2C18 is an efficient methoxychlor demethylase, its expression in liver is reportedly low or absent, suggesting a negligible role for this enzyme in methoxychlor metabolism. Methoxychlor cytochrome P450 family 2 subfamily C member 18 Homo sapiens