PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9671519-2 1998 While the palmitoyl protein thioesterase(s) responsible for depalmitoylation of plasma membrane-associated signaling proteins has (have) not been identified, the lysosomal palmitoyl protein thioesterase 1 (PPT1) has proven useful in in vitro studies of membrane localization requirements of GTP-binding proteins. Guanosine Triphosphate 291-294 palmitoyl-protein thioesterase 1 Homo sapiens 172-204 9671519-2 1998 While the palmitoyl protein thioesterase(s) responsible for depalmitoylation of plasma membrane-associated signaling proteins has (have) not been identified, the lysosomal palmitoyl protein thioesterase 1 (PPT1) has proven useful in in vitro studies of membrane localization requirements of GTP-binding proteins. Guanosine Triphosphate 291-294 palmitoyl-protein thioesterase 1 Homo sapiens 206-210 9671519-5 1998 Didemnin B was shown to inhibit recombinant human PPT1 with a Ki of 92 nM. didemnins 0-10 palmitoyl-protein thioesterase 1 Homo sapiens 50-54 9671519-6 1998 Kinetic analysis of this inhibition revealed that didemnin B inhibits PPT1 uncompetitively. didemnins 50-60 palmitoyl-protein thioesterase 1 Homo sapiens 70-74 9671519-8 1998 As the first described inhibitor of PPT1, didemnin B may prove to be a useful tool in the investigation of protein palmitoylation regulation. didemnins 42-52 palmitoyl-protein thioesterase 1 Homo sapiens 36-40