Title : Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.

Pub. Date : 1998 Feb 19

PMID : 9486652






5 Functional Relationships(s)
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1 Consistent with the faster dissociation of PIP2 from the GIRK channels, the carboxy terminus of GIRK1 binds 3H-PIP2 liposomes more weakly than does that of IRK1 or ROMK1. Phosphatidylinositol 4,5-Diphosphate potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
2 Consistent with the faster dissociation of PIP2 from the GIRK channels, the carboxy terminus of GIRK1 binds 3H-PIP2 liposomes more weakly than does that of IRK1 or ROMK1. 3h-pip2 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
3 When GIRK1/4 channels are allowed to run down completely, they are not activated by addition of Gbetagamma alone, but application of PIP2 activates them in minutes without Gbetagamma and in just seconds with Gbetagamma. Phosphatidylinositol 4,5-Diphosphate potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
4 When GIRK1/4 channels are allowed to run down completely, they are not activated by addition of Gbetagamma alone, but application of PIP2 activates them in minutes without Gbetagamma and in just seconds with Gbetagamma. gbetagamma potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
5 When GIRK1/4 channels are allowed to run down completely, they are not activated by addition of Gbetagamma alone, but application of PIP2 activates them in minutes without Gbetagamma and in just seconds with Gbetagamma. gbetagamma potassium inwardly rectifying channel subfamily J member 3 Homo sapiens