Title : Transcriptional repression by the promyelocytic leukemia protein, PML.

Pub. Date : 1997 Dec 15

PMID : 9434633






2 Functional Relationships(s)
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1 The magnitude of this repression is cell type and promoter dependent, and deletion studies show that the putative coiled-coil and part of the serine-rich regions of PML are required for this activity. Serine PML nuclear body scaffold Homo sapiens
2 The data presented also demonstrate that GAL4/PML can recruit PMLRAR alpha resulting in the retinoid-inducible transcriptional activation of a GAL4-responsive promoter, a function dependent on the presence of the coiled-coil region of PMLRAR alpha. Retinoids PML nuclear body scaffold Homo sapiens