Title : Cystine starvation induces reversible large-body formation from nuclear bodies in T24 cells.

Pub. Date : 1997 Nov 25

PMID : 9417884






5 Functional Relationships(s)
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1 Both PML and Sp100 exhibit the same behavior as that of the nuclear body antigen(s) of AP435 MAb with regard to these changes, L-buthionine-[S,R]-sulfoximine, an inhibitor of glutathione synthesis, also induced the formation of large bodies that could be reversed to nuclear bodies by both beta-mercaptoethanol and dithiothreitol as well as cystine. SCHEMBL115963 PML nuclear body scaffold Homo sapiens
2 Both PML and Sp100 exhibit the same behavior as that of the nuclear body antigen(s) of AP435 MAb with regard to these changes, L-buthionine-[S,R]-sulfoximine, an inhibitor of glutathione synthesis, also induced the formation of large bodies that could be reversed to nuclear bodies by both beta-mercaptoethanol and dithiothreitol as well as cystine. Glutathione PML nuclear body scaffold Homo sapiens
3 Both PML and Sp100 exhibit the same behavior as that of the nuclear body antigen(s) of AP435 MAb with regard to these changes, L-buthionine-[S,R]-sulfoximine, an inhibitor of glutathione synthesis, also induced the formation of large bodies that could be reversed to nuclear bodies by both beta-mercaptoethanol and dithiothreitol as well as cystine. Mercaptoethanol PML nuclear body scaffold Homo sapiens
4 Both PML and Sp100 exhibit the same behavior as that of the nuclear body antigen(s) of AP435 MAb with regard to these changes, L-buthionine-[S,R]-sulfoximine, an inhibitor of glutathione synthesis, also induced the formation of large bodies that could be reversed to nuclear bodies by both beta-mercaptoethanol and dithiothreitol as well as cystine. Dithiothreitol PML nuclear body scaffold Homo sapiens
5 Both PML and Sp100 exhibit the same behavior as that of the nuclear body antigen(s) of AP435 MAb with regard to these changes, L-buthionine-[S,R]-sulfoximine, an inhibitor of glutathione synthesis, also induced the formation of large bodies that could be reversed to nuclear bodies by both beta-mercaptoethanol and dithiothreitol as well as cystine. Cystine PML nuclear body scaffold Homo sapiens