Title : Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

Pub. Date : 1997 Dec

PMID : 9415395






4 Functional Relationships(s)
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Protein Name
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1 Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). peroxovanadium protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
2 Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). bromopyruvate protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
3 We have established the existence of an insulin receptor kinase (IRK)-associated PTP whose inhibition by pVs correlates closely with IRK tyrosine phosphorylation, activation, and downstream signaling. Tyrosine protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
4 bpV(phen) could be distinguished from insulin only in its ability to activate ERK1 in HTC-M1030 cells, thus indicating that this event is IRK independent, consistent with our previous hypothesis that bpV(phen) inhibits a PTP involved in the negative regulation of mitogen-activated protein kinases. bromopyruvate protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus