Title : Functional compartmentalization of ATP is involved in angiotensin II-mediated closure of cardiac ATP-sensitive K+ channels.

Pub. Date : 1997 Nov 4

PMID : 9386185






4 Functional Relationships(s)
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Protein Name
Organism
1 CV11974 (100 nmol/L), an angiotensin 1 (AT1) receptor-selective antagonist, blocked the inhibitory action of Ang II. candesartan type-1 angiotensin II receptor Cavia porcellus
2 CV11974 (100 nmol/L), an angiotensin 1 (AT1) receptor-selective antagonist, blocked the inhibitory action of Ang II. candesartan type-1 angiotensin II receptor Cavia porcellus
3 CONCLUSIONS: The inhibitory actions of Ang II on K(ATP) appear to be mediated by an increase in the subsarcolemmal ATP concentration that results from the inhibition of adenylate cyclase activities via AT1 receptors/PTX-sensitive G proteins. Adenosine Triphosphate type-1 angiotensin II receptor Cavia porcellus
4 CONCLUSIONS: The inhibitory actions of Ang II on K(ATP) appear to be mediated by an increase in the subsarcolemmal ATP concentration that results from the inhibition of adenylate cyclase activities via AT1 receptors/PTX-sensitive G proteins. Adenosine Triphosphate type-1 angiotensin II receptor Cavia porcellus