Pub. Date : 1997 Nov
PMID : 9369431
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 4 | Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 5 | Immunostaining of NB4/RA cells using anti-PML antibody showed a microgranular pattern which was not restored even by the combination of RA and 8-CPT-cAMP, whereas the microgranular pattern in NB4 cells was rapidly restored to the normal speckled pattern by RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 6 | Immunostaining of NB4/RA cells using anti-PML antibody showed a microgranular pattern which was not restored even by the combination of RA and 8-CPT-cAMP, whereas the microgranular pattern in NB4 cells was rapidly restored to the normal speckled pattern by RA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 7 | These data suggest that differentiation of APL by RA is triggered directly through PML-RARalpha, and is associated with its degradation. | Tretinoin | PML nuclear body scaffold | Homo sapiens |