Title : In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Pub. Date : 1997 Oct

PMID : 9321523






2 Functional Relationships(s)
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1 Both CYP3A4 and CYP3A5 were capable of catalyzing the formation of 3",5"-dihydrodiol, 3"-hydroxy, and 6"-exomethylene metabolites. 3",5"-dihydrodiol cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 Both CYP3A4 and CYP3A5 were capable of catalyzing the formation of 3",5"-dihydrodiol, 3"-hydroxy, and 6"-exomethylene metabolites. 3"-hydroxy, and 6"-exomethylene cytochrome P450 family 3 subfamily A member 5 Homo sapiens