Title : Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart.

Pub. Date : 1997 Oct

PMID : 9314843






2 Functional Relationships(s)
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1 Both cilazapril (angiotensin II-converting enzyme inhibitor) and E4177 (angiotensin II type 1 [AT1] receptor antagonist) significantly suppressed the phosphorylation of Tyk2 and partially inhibited the phosphorylation of JAK2, but neither affected JAK1. Cilazapril Janus kinase 2 Rattus norvegicus
2 Both cilazapril (angiotensin II-converting enzyme inhibitor) and E4177 (angiotensin II type 1 [AT1] receptor antagonist) significantly suppressed the phosphorylation of Tyk2 and partially inhibited the phosphorylation of JAK2, but neither affected JAK1. 3-((2'-carboxybiphenyl-4-yl)methyl)-2-cyclopropyl-7-methyl-3H-imidazo(4,5-b)pyridine Janus kinase 2 Rattus norvegicus