Title : The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes.

Pub. Date : 1997 Sep

PMID : 9299374






2 Functional Relationships(s)
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1 Jak2 was also tyrosine phosphorylated eight-fold by angiotensin II treatment, and phosphorylated Stat1 and Stat3 proteins co-immunoprecipitated with activated Jak2 kinase. Tyrosine Janus kinase 2 Rattus norvegicus
2 Selective inhibition of Jak2 kinase with AG-490 blocked formation of angiotensin II induced SIF complexes, suggesting that Jak2 kinase is required for cardiomyocyte SIF induction. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide Janus kinase 2 Rattus norvegicus