Pub. Date : 1997 Sep
PMID : 9287988
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment with either the antioxidant N-acetyl cysteine or IL-1RA was sufficient to prevent almost completely down-regulation of IRP activity. | Acetylcysteine | caspase 3 | Rattus norvegicus |
| 2 | However, induction of ferritin gene transcription, possibly mediated by ferritin-derived iron and ROS-mediated inactivation of IRP, which allows translation of ferritin mRNAs, counteracts this effect and concurs to reestablish the amount of ferritin, which may thus act to limit reperfusion damage. | Reactive Oxygen Species | caspase 3 | Rattus norvegicus |