Title : Induction of ferritin synthesis in ischemic-reperfused rat liver: analysis of the molecular mechanisms.

Pub. Date : 1997 Sep

PMID : 9287988






2 Functional Relationships(s)
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1 Pretreatment with either the antioxidant N-acetyl cysteine or IL-1RA was sufficient to prevent almost completely down-regulation of IRP activity. Acetylcysteine caspase 3 Rattus norvegicus
2 However, induction of ferritin gene transcription, possibly mediated by ferritin-derived iron and ROS-mediated inactivation of IRP, which allows translation of ferritin mRNAs, counteracts this effect and concurs to reestablish the amount of ferritin, which may thus act to limit reperfusion damage. Reactive Oxygen Species caspase 3 Rattus norvegicus