Title : Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor.

Pub. Date : 1997 Sep 12

PMID : 9287353






3 Functional Relationships(s)
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1 Angiotensin II, acting through the AT1 receptor, also stimulates the Jak/STAT pathway by inducing ligand-dependent Jak2 tyrosine phosphorylation and activation. Tyrosine Janus kinase 2 Rattus norvegicus
2 The wild-type AT1A receptor can induce Jak2 tyrosine phosphorylation. Tyrosine Janus kinase 2 Rattus norvegicus
3 Competition experiments with synthetic peptides suggest that each of the YIPP amino acids, including tyrosine 319, is important in Jak2 binding to the AT1A receptor. Tyrosine Janus kinase 2 Rattus norvegicus