Title : Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1.

Pub. Date : 1997 Jul

PMID : 9255599






6 Functional Relationships(s)
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1 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. nipecotic acid solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
2 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. nipecotic acid solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
3 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. 2-(N-morpholino)ethanesulfonic acid solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
4 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. 2-(N-morpholino)ethanesulfonic acid solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
5 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. 1,2,5,6-dibenzanthracene solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus
6 Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice. 1,2,5,6-dibenzanthracene solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Mus musculus