Pub. Date : 1997 Aug 1
PMID : 9242550
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | T-RA is an effective inducer of clinical remission only in patients carrying the t(15;17) and expressing the PML/RAR alpha products. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | Moreover, two different high-affinity 9-cis-RA binding sites (Kd = 0.45 and 0.075 nmol/L) were detectable in the bcr3-PML/RAR alpha product but not in the bcr1-PML/RAR alpha product (Kd = 0.77 nmol/L). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | Moreover, two different high-affinity 9-cis-RA binding sites (Kd = 0.45 and 0.075 nmol/L) were detectable in the bcr3-PML/RAR alpha product but not in the bcr1-PML/RAR alpha product (Kd = 0.77 nmol/L). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 4 | By competition binding experiments we showed that 9-cis-RA binds with higher specificity to the bcr3-PML/RAR alpha isoform than to the bcr1-PML/RAR alpha or RAR alpha. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 5 | These results provide evidence indicating that preferential retinoid binding to the different PML/RAR alpha products can be measured. | Retinoids | PML nuclear body scaffold | Homo sapiens |