Title : Insulin and interleukin-4 induce desensitization to the mitogenic effects of insulin-like growth factor-I. Pivotal role for insulin receptor substrate-2.

Pub. Date : 1997 Aug 1

PMID : 9235956






3 Functional Relationships(s)
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Protein Name
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1 Pretreatment of bovine fibroblasts with 10 nM insulin for 48 h blocked subsequent IGF-I-stimulated DNA synthesis and the IGF-I-induced increase in tyrosyl-phosphorylated IRS-2. cyclo(tyrosyl-tyrosyl) insulin receptor substrate 2 Bos taurus
2 The interleukin-4 (IL-4) cytokine receptor also has IRS-2 as its major substrate for tyrosine phosphorylation. Tyrosine insulin receptor substrate 2 Bos taurus
3 LY294002 also prevented the shift in IRS-2 molecular mass in response to prolonged incubation of cells with insulin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one insulin receptor substrate 2 Bos taurus