Title : Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

Pub. Date : 1997 May

PMID : 9145912






1 Functional Relationships(s)
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1 We report that treatment of Caco-2 cells with 1 alpha,25-dihydroxyvitamin D3, beginning at confluence, results in a dose- and duration-dependent increase in CYP3A4 mRNA and protein, with little apparent effect on the expression of CYP3A5 or CYP3A7. Calcitriol cytochrome P450 family 3 subfamily A member 5 Homo sapiens