Title : Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

Pub. Date : 1997 Mar 18

PMID : 9122220






2 Functional Relationships(s)
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Protein Name
Organism
1 Expression of this form of gp130 in lymphocytes significantly suppressed interleukin 6-induced tyrosine phosphorylation of endogenous gp130 and a downstream signaling molecule, signal transducer and activator of transcription 3, indicating that this form has a dominant negative function. Tyrosine interleukin 6 signal transducer Mus musculus
2 Expression of this form of gp130 in lymphocytes significantly suppressed interleukin 6-induced tyrosine phosphorylation of endogenous gp130 and a downstream signaling molecule, signal transducer and activator of transcription 3, indicating that this form has a dominant negative function. Tyrosine interleukin 6 signal transducer Mus musculus