Title : Rat mesangial cells and matrix metalloproteinase inhibitor: inhibition of 72-kD type IV collagenase (MMP-2) and of cell proliferation.

Pub. Date : 1997 Mar

PMID : 9071708






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 The synthetic inhibitor of matrix metalloproteinases (MMP) Ro 31-9790, a hydroxamic-acid derivative, was investigated for its effect on rat mesangial cells (MC) in culture. Hydroxamic Acids matrix metallopeptidase 2 Rattus norvegicus
2 Ro 31-9790 inhibited activity of the rat MC MMP-2 in a concentration-dependent and competitive fashion, as analyzed by quantitative densitometry and by a continuously recording fluorescent assay. Ro 31-9790 matrix metallopeptidase 2 Rattus norvegicus