Title : Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

Pub. Date : 1997 Mar

PMID : 9056009






2 Functional Relationships(s)
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1 In rat and human liver microsomes, ritonavir potently inhibited the cytochrome P450 (CYP)-mediated metabolism of saquinavir, indinavir, nelfinavir, and VX-478. Nelfinavir cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 In rat and human liver microsomes, ritonavir potently inhibited the cytochrome P450 (CYP)-mediated metabolism of saquinavir, indinavir, nelfinavir, and VX-478. Nelfinavir cytochrome P450 family 4 subfamily F member 3 Homo sapiens