Pub. Date : 1997 Jan
PMID : 9038938
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATP-dependent regulation of a G protein-coupled K+ channel (GIRK1/GIRK4) expressed in oocytes. | Adenosine Triphosphate | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | In cell-attached patches with ACh in the pipette, the mean open times (tau zero) of GIRK1/GIRK4 were 1.2 +/- 0.1 (28%) and 6.7 +/- 0.8 ms (72%) and did not change significantly with time. | Acetylcholine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | However, in inside-out patches, the tau zero of GIRK1/GIRK4 activated with guanosine 5"-O-(3-thiotriphosphate) was 1.3 +/- 0.1 ms (100%), and the channel activity (NP0) was almost fivefold lower. | Guanosine 5'-O-(3-Thiotriphosphate) | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | Addition of 1 mM ATP, but not adenylimidodiphosphate, to inside-out patches resulted in increases in NP zero (4.8-fold) and the open-time duration of GIRK1/GIRK4, such that tau zero were 1.2 +/- 0.2 (32%) and 6.2 +/- 0.6 ms (68%). | Adenosine Triphosphate | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | In oocytes the ATP-dependent step is dominant and thus provides a major component of the total GIRK1/GIRK4 current activated by ACh. | Adenosine Triphosphate | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 6 | In oocytes the ATP-dependent step is dominant and thus provides a major component of the total GIRK1/GIRK4 current activated by ACh. | Acetylcholine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |