Title : Enhanced inhibition of microsomal cytochrome P450 3A2 in rat liver during diltiazem biotransformation.

Pub. Date : 1996 Dec

PMID : 8968370






1 Functional Relationships(s)
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1 This P450 appeared to be the preferred target for inhibition, because the observed K/K(m) ratio for inhibition of CYP3A2-dependent steroid hydroxylation was approximately 4- and 100-fold lower than those for CYP2C11 and CYP2A1-dependent pathways, respectively. Steroids cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus