Title : Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity.

Pub. Date : 1996 Dec

PMID : 8951224






2 Functional Relationships(s)
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1 U-89843 has been shown to undergo C-6 methylhydroxylation to give U-97924, in rat both in vivo and in vitro, in a reaction catalyzed by cytochrome P450 2C11. U 89843 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 U-89843 has been shown to undergo C-6 methylhydroxylation to give U-97924, in rat both in vivo and in vitro, in a reaction catalyzed by cytochrome P450 2C11. U-97924 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus