Pub. Date : 1996 Nov 29
PMID : 8940037
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In both cell lines, insulin significantly increased p21(ras).GTP loading (1.5-2-fold) and MAP kinase activity (5-8-fold). | Guanosine Triphosphate | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | Inhibition of Ras farnesylation with lovastatin blocked activation of p21(ras) and Raf-1 kinase in both 3T3-L1 fibroblasts and 3T3-L1 adipocytes. | Lovastatin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | In contrast, in 3T3-L1 adipocytes, despite an inhibition of activation of p21(ras) and Raf-1 by lovastatin, insulin continued to stimulate MAP kinase activity. | Lovastatin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |