PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8940037-2 1996 In both cell lines, insulin significantly increased p21(ras).GTP loading (1.5-2-fold) and MAP kinase activity (5-8-fold). Guanosine Triphosphate 61-64 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 52-55 8940037-3 1996 Inhibition of Ras farnesylation with lovastatin blocked activation of p21(ras) and Raf-1 kinase in both 3T3-L1 fibroblasts and 3T3-L1 adipocytes. Lovastatin 37-47 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 70-73 8940037-3 1996 Inhibition of Ras farnesylation with lovastatin blocked activation of p21(ras) and Raf-1 kinase in both 3T3-L1 fibroblasts and 3T3-L1 adipocytes. Lovastatin 37-47 v-raf-leukemia viral oncogene 1 Mus musculus 83-88 8940037-5 1996 In contrast, in 3T3-L1 adipocytes, despite an inhibition of activation of p21(ras) and Raf-1 by lovastatin, insulin continued to stimulate MAP kinase activity. Lovastatin 96-106 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 74-77 8940037-5 1996 In contrast, in 3T3-L1 adipocytes, despite an inhibition of activation of p21(ras) and Raf-1 by lovastatin, insulin continued to stimulate MAP kinase activity. Lovastatin 96-106 v-raf-leukemia viral oncogene 1 Mus musculus 87-92 8940037-6 1996 Fractionation of the cell lysates on the FPLC Mono-Q column revealed that lovastatin inhibited insulin stimulation of ERK2 (and, to a lesser extent, ERK1) in 3T3-L1 fibroblasts and had no effect on the insulin-stimulated ERK2 in 3T3-L1 adipocytes. Lovastatin 74-84 mitogen-activated protein kinase 1 Mus musculus 118-122 8940037-6 1996 Fractionation of the cell lysates on the FPLC Mono-Q column revealed that lovastatin inhibited insulin stimulation of ERK2 (and, to a lesser extent, ERK1) in 3T3-L1 fibroblasts and had no effect on the insulin-stimulated ERK2 in 3T3-L1 adipocytes. Lovastatin 74-84 mitogen-activated protein kinase 3 Mus musculus 149-153 8940037-6 1996 Fractionation of the cell lysates on the FPLC Mono-Q column revealed that lovastatin inhibited insulin stimulation of ERK2 (and, to a lesser extent, ERK1) in 3T3-L1 fibroblasts and had no effect on the insulin-stimulated ERK2 in 3T3-L1 adipocytes. Lovastatin 74-84 mitogen-activated protein kinase 1 Mus musculus 221-225