Title : Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.

Pub. Date : 1996 Jan-Feb

PMID : 8924622






1 Functional Relationships(s)
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1 Reconstitution experiments with cytochrome P450BTL, which belongs to the P4502D subfamily, and P450m1 (P4502C11) demonstrated that MPTP N-demethylase occurs at concentrations of 5 microM and 5 mM. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus