Title : [Effect of PML and PML-RAR on the transactivation properties and subcellular localization of steroid hormone receptors].

Pub. Date : 1996

PMID : 8881287






3 Functional Relationships(s)
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1 Use of deletion mutants showed that both activation functions (AF1 and AF2) of PR as well as the coiled coil and His-Cys rich domains of PML were required for transcriptional enhancement. Histidine PML nuclear body scaffold Homo sapiens
2 Use of deletion mutants showed that both activation functions (AF1 and AF2) of PR as well as the coiled coil and His-Cys rich domains of PML were required for transcriptional enhancement. Cysteine PML nuclear body scaffold Homo sapiens
3 The fusion protein PML-RAR, which is not localized in nuclear bodies, also enhanced the transactivating activity of PR but this effect was totally suppressed by the administration of retinoic acid. Tretinoin PML nuclear body scaffold Homo sapiens