Title : The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells.

Pub. Date : 1996 Oct 15

PMID : 8874178






3 Functional Relationships(s)
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1 We now show that the PML/RAR alpha fusion product is directly downregulated in response to retinoic acid (tRA) treatment in the human APL cell line, NB4. Tretinoin PML nuclear body scaffold Homo sapiens
2 We now show that the PML/RAR alpha fusion product is directly downregulated in response to retinoic acid (tRA) treatment in the human APL cell line, NB4. territrem A PML nuclear body scaffold Homo sapiens
3 The loss of PML/RAR alpha may be directly linked to tRA-induced differentiation, because in a retinoid-resistant subclone of NB4, tRA does not decrease PML/RAR alpha protein expression. Retinoids PML nuclear body scaffold Homo sapiens