Pub. Date : 1996 Sep
PMID : 8870981
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase. | Guanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 2 | Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase. | 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 3 | Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 4 | Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 5 | Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 6 | Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 7 | The model pyridyloxobutylating agent, 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), was reacted with either poly(dAdT) or poly(dGdC) to generate DNA substrates for reaction with AGT. | 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 8 | The model pyridyloxobutylating agent, 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), was reacted with either poly(dAdT) or poly(dGdC) to generate DNA substrates for reaction with AGT. | 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 9 | Only the pyridyloxobutylated poly(dGdC) was able to prevent the ability of partially purified rat liver AGT to repair O6-mG. | poly(dC-dG) | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 10 | These results demonstrate that pyridyloxobutylation of only guanine residues produces adducts that react with AGT. | Guanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 11 | These AGT-reactive guanine adducts are relatively stable within DNA, with a half-life of 1-2 weeks at 37 degrees C. They represent up to 70% of the total HPB-releasing adducts in the NNKOAc-treated DNA. | Guanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 12 | These AGT-reactive guanine adducts are relatively stable within DNA, with a half-life of 1-2 weeks at 37 degrees C. They represent up to 70% of the total HPB-releasing adducts in the NNKOAc-treated DNA. | 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 13 | We postulate that a potential AGT-reactive adduct is an O6-(pyridyloxobutyl)guanine adduct. | o6-(pyridyloxobutyl)guanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |