PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8870981-0	1996	Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.	Guanine	24-31	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	124-160	
8870981-0	1996	Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.	4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	44-99	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	124-160	
8870981-1	1996	Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG).	O-(6)-methylguanine	128-144	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	59-96	
8870981-1	1996	Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG).	O-(6)-methylguanine	128-144	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	98-101	
8870981-1	1996	Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG).	O-(6)-methylguanine	146-151	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	59-96	
8870981-1	1996	Pyridyloxobutylation of DNA yields adducts that react with O6-alkylguanine-DNA alkyl-transferase (AGT) to prevent the repair of O6-methylguanine (O6-mG).	O-(6)-methylguanine	146-151	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	98-101	
8870981-5	1996	The model pyridyloxobutylating agent, 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), was reacted with either poly(dAdT) or poly(dGdC) to generate DNA substrates for reaction with AGT.	4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	38-93	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	198-201	
8870981-5	1996	The model pyridyloxobutylating agent, 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), was reacted with either poly(dAdT) or poly(dGdC) to generate DNA substrates for reaction with AGT.	4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	95-101	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	198-201	
8870981-6	1996	Only the pyridyloxobutylated poly(dGdC) was able to prevent the ability of partially purified rat liver AGT to repair O6-mG.	poly(dC-dG)	29-39	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	104-107	
8870981-12	1996	These results demonstrate that pyridyloxobutylation of only guanine residues produces adducts that react with AGT.	Guanine	60-67	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	110-113	
8870981-13	1996	These AGT-reactive guanine adducts are relatively stable within DNA, with a half-life of 1-2 weeks at 37 degrees C. They represent up to 70% of the total HPB-releasing adducts in the NNKOAc-treated DNA.	Guanine	19-26	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	6-9	
8870981-13	1996	These AGT-reactive guanine adducts are relatively stable within DNA, with a half-life of 1-2 weeks at 37 degrees C. They represent up to 70% of the total HPB-releasing adducts in the NNKOAc-treated DNA.	4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	183-189	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	6-9	
8870981-14	1996	We postulate that a potential AGT-reactive adduct is an O6-(pyridyloxobutyl)guanine adduct.	o6-(pyridyloxobutyl)guanine	56-83	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	30-33