Title : Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

Pub. Date : 1996 Sep 17

PMID : 8816811






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Heme oxygenase-1 (HO-1) is inducible not only by its heme substrate, but also by a variety of agents causing oxidative stress. Heme heme oxygenase 1 Homo sapiens
2 Heme oxygenase-1 (HO-1) is inducible not only by its heme substrate, but also by a variety of agents causing oxidative stress. Heme heme oxygenase 1 Homo sapiens
3 Tin protoporphyrin, a selective inhibitor of HO, reversed the growth arrest and ablated the increased survival against hyperoxia observed in the A549-A4 cells overexpressing HO-1. tin protoporphyrin IX heme oxygenase 1 Homo sapiens
4 Taken together, our data suggest that overexpression of HO-1 results in cell growth arrest, which may facilitate cellular protection against non-heme-mediated oxidant insult such as hyperoxia. Heme heme oxygenase 1 Homo sapiens