Title : Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats.

Pub. Date : 1996 Jun

PMID : 8800366






8 Functional Relationships(s)
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1 Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats. Glucose insulin 2 Rattus norvegicus
2 Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats. Streptozocin insulin 2 Rattus norvegicus
3 Recent studies suggest that C-peptide stimulates glucose transport in isolated skeletal muscle. Glucose insulin 2 Rattus norvegicus
4 The metabolic clearance rate of glucose (MCR) for the diabetic rats receiving C-peptide (12.0 +/- 1.0 mL kg-1 min-1) was significantly (P < 0.01) higher than that in the diabetic rats given saline (6.3 +/- 0.7 mL kg-1 min-1) or a randomly scrambled C-peptide (7.8 +/- 1.3 mL kg-1 min-1) at low-dose insulin infusion but not at the high-dose insulin infusion. Glucose insulin 2 Rattus norvegicus
5 The metabolic clearance rate of glucose (MCR) for the diabetic rats receiving C-peptide (12.0 +/- 1.0 mL kg-1 min-1) was significantly (P < 0.01) higher than that in the diabetic rats given saline (6.3 +/- 0.7 mL kg-1 min-1) or a randomly scrambled C-peptide (7.8 +/- 1.3 mL kg-1 min-1) at low-dose insulin infusion but not at the high-dose insulin infusion. Glucose insulin 2 Rattus norvegicus
6 The metabolic clearance rate of glucose (MCR) for the diabetic rats receiving C-peptide (12.0 +/- 1.0 mL kg-1 min-1) was significantly (P < 0.01) higher than that in the diabetic rats given saline (6.3 +/- 0.7 mL kg-1 min-1) or a randomly scrambled C-peptide (7.8 +/- 1.3 mL kg-1 min-1) at low-dose insulin infusion but not at the high-dose insulin infusion. Sodium Chloride insulin 2 Rattus norvegicus
7 These results thus demonstrate that C-peptide has the capacity to increase glucose utilization in STZ-induced diabetic rats. Glucose insulin 2 Rattus norvegicus
8 These results thus demonstrate that C-peptide has the capacity to increase glucose utilization in STZ-induced diabetic rats. Streptozocin insulin 2 Rattus norvegicus