Protein Name insulin 2
Organism Rattus norvegicus
Gene ID 24506
Gene Symbol

Ins2

UniProt P01323 (INS2_RAT)
Relationships Total Number of functionally related compound(s) : 98
Total Number of Articles : 100
Description

insulin 2

Gene Summary

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of catabolic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • insulin-2
  • C-peptide
  • CP-II
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Properties