Pub. Date : 1996 Sep 6
PMID : 8797825
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 2 | In T lymphocytes, NF-kappa B is sequestered in the cytosol by the inhibitor I kappa B-alpha and released after serine phosphorylation of I kappa B-alpha that regulates its ubiquitin-dependent degradation. | Serine | NFKB inhibitor alpha | Homo sapiens |
| 3 | Stimulation of Jurkat T cells with the protein tyrosine phosphatase inhibitor and T cell activator pervanadate led to NF-kappa B activation through tyrosine phosphorylation but not degradation of I kappa B-alpha. | pervanadate | NFKB inhibitor alpha | Homo sapiens |
| 4 | Pervanadate-induced I kappa B-alpha phosphorylation and NF-kappa B activation required expression of the T cell tyrosine kinase p56ick. | pervanadate | NFKB inhibitor alpha | Homo sapiens |
| 5 | Reoxygenation of hypoxic cells appeared as a physiological effector of I kappa B-alpha tyrosine phosphorylation. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 6 | Tyrosine phosphorylation of I kappa B-alpha represents a proteolysis-independent mechanism of NF-kappa B activation that directly couples NF-kappa B to cellular tyrosine kinase. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |