Pub. Date : 1996 Jun
PMID : 8793745
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The complex patterns of sensitivity to cyclothiazide seen in hippocampal neurons could be reconstituted by assembly of recombinant AMPA receptor subunits generated from cDNAs encoding the flip (i) and flop (o) splice variants of the GluR-A and GluR-B subunits. | cyclothiazide | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | Coexpression of the flip and flop splice variants of GluR-A, in the absence of GluR-B, revealed that heteromeric AMPA receptors with intermediate sensitivity to cyclothiazide, similar to responses observed for the combinations GluR-AoBi or GluR-AiBo, could be generated independently of the presence of the GluR-B subunit. | cyclothiazide | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | However, recovery from modulation by cyclothiazide was twofold slower for GluR-AiBi than for homomeric GluR-Ai, indicating that the GluR-A and GluR-B subunits are not functionally equivalent in controlling sensitivity to cyclothiazide. | cyclothiazide | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |