Title : Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

Pub. Date : 1996 Aug 1

PMID : 8758899






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Insulin-like growth factors initiate tyrosyl phosphorylation of the insulin receptor substrate I (IRS-I) protein and activate multiple signaling pathways essential for liver growth. cyclo(tyrosyl-tyrosyl) isoleucyl-tRNA synthetase 1 Homo sapiens
2 The overexpressed IRS-I protein was highly tyrosyl phosphorylated following insulin/insulin- like growth factor I stimulation and led to constitutive activation of downstream signal transduction molecules such as phosphatidylinositol-3 kinase and mitogen-activated protein kinase. cyclo(tyrosyl-tyrosyl) isoleucyl-tRNA synthetase 1 Homo sapiens