| Protein Name | isoleucyl-tRNA synthetase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3376 |
| Gene Symbol | IARS1 |
| UniProt | P41252 (SYIC_HUMAN), Q7L4K8 (Q7L4K8_HUMAN), Q6P0M4 (Q6P0M4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
142
Total Number of Articles : 141 |
Description |
isoleucyl-tRNA synthetase 1 |
| Gene Summary |
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012] |
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| Properties | |