Title : Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans.

Pub. Date : 1995 Dec

PMID : 8750925






2 Functional Relationships(s)
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Protein Name
Organism
1 Anti-LKM2 (anti-liver/kidney microsome) autoantibodies (which inhibit CYP2C9 and 2C19) and sulfaphenazole (a specific CYP2C9 inhibitor) reduced the maximum rate of formation of D-703 by 81.5 +/- 4.5% and 45%, that of D-702 by 52.7 +/- 7.5% and 72.5%, respectively. D 703 cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Anti-LKM2 (anti-liver/kidney microsome) autoantibodies (which inhibit CYP2C9 and 2C19) and sulfaphenazole (a specific CYP2C9 inhibitor) reduced the maximum rate of formation of D-703 by 81.5 +/- 4.5% and 45%, that of D-702 by 52.7 +/- 7.5% and 72.5%, respectively. Sulfaphenazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens