Title : Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat.

Pub. Date : 1996 May

PMID : 8736062






1 Functional Relationships(s)
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1 The major male-specific CYP isozyme, 2C11, was down-regulated by MTX treatment as revealed by a marginal (25%), but statistically significant decrease in AD 16 alpha-hydroxylase activity at day 14 and a marginal (18%), but statistically significant decrease in CYP2C11 mRNA content at day 14. Methotrexate cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus