Pub. Date : 1996 Apr
PMID : 8730126
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: Alkaline phosphatase (ALP), an enzyme with pyrophosphatase (PPiase) activity can dissolve calcium pyrophosphate dihydrate (CPPD) crystals. | Calcium Pyrophosphate | FKBP prolyl isomerase 1B | Homo sapiens |
| 2 | OBJECTIVE: Alkaline phosphatase (ALP), an enzyme with pyrophosphatase (PPiase) activity can dissolve calcium pyrophosphate dihydrate (CPPD) crystals. | Calcium Pyrophosphate | FKBP prolyl isomerase 1B | Homo sapiens |
| 3 | We studied the effects of enzyme inhibitors such as bisphosphonates, orthovanadate, calcium, cadmium, and ascorbic acid on PPiase activity of ALP as well as on phosphate ester hydrolysis (Pase) activity and compared these effects to those on CPPD crystal dissolution. | Diphosphonates | FKBP prolyl isomerase 1B | Homo sapiens |
| 4 | We studied the effects of enzyme inhibitors such as bisphosphonates, orthovanadate, calcium, cadmium, and ascorbic acid on PPiase activity of ALP as well as on phosphate ester hydrolysis (Pase) activity and compared these effects to those on CPPD crystal dissolution. | Calcium | FKBP prolyl isomerase 1B | Homo sapiens |
| 5 | We studied the effects of enzyme inhibitors such as bisphosphonates, orthovanadate, calcium, cadmium, and ascorbic acid on PPiase activity of ALP as well as on phosphate ester hydrolysis (Pase) activity and compared these effects to those on CPPD crystal dissolution. | Cadmium | FKBP prolyl isomerase 1B | Homo sapiens |
| 6 | We studied the effects of enzyme inhibitors such as bisphosphonates, orthovanadate, calcium, cadmium, and ascorbic acid on PPiase activity of ALP as well as on phosphate ester hydrolysis (Pase) activity and compared these effects to those on CPPD crystal dissolution. | Ascorbic Acid | FKBP prolyl isomerase 1B | Homo sapiens |
| 7 | Calcium inhibited ALP PPiase activity, but not ALP Pase activity. | Calcium | FKBP prolyl isomerase 1B | Homo sapiens |
| 8 | Orthovanadate and cadmium inhibited ALP PPiase activity more than ALP Pase at the same concentrations. | Vanadates | FKBP prolyl isomerase 1B | Homo sapiens |
| 9 | Orthovanadate and cadmium inhibited ALP PPiase activity more than ALP Pase at the same concentrations. | Cadmium | FKBP prolyl isomerase 1B | Homo sapiens |
| 10 | The inhibition rates of ALP PPiase at the same concentrations were orthovanadate > cadmium > calcium. | Vanadates | FKBP prolyl isomerase 1B | Homo sapiens |
| 11 | The inhibition rates of ALP PPiase at the same concentrations were orthovanadate > cadmium > calcium. | Cadmium | FKBP prolyl isomerase 1B | Homo sapiens |
| 12 | The inhibition rates of ALP PPiase at the same concentrations were orthovanadate > cadmium > calcium. | Calcium | FKBP prolyl isomerase 1B | Homo sapiens |
| 13 | Although ALP Pase activity was not inhibited, at high concentrations, ascorbic acid slightly inhibited ALP PPiase activity. | Ascorbic Acid | FKBP prolyl isomerase 1B | Homo sapiens |
| 14 | The strong inhibitory effects of bisphosphonates on ALP CPPD crystal dissolution compared to those on ALP PPiase activity suggest that bisphosphonates inhibit crystal dissolution by their affinity for the CPPD crystal surface. | Diphosphonates | FKBP prolyl isomerase 1B | Homo sapiens |