Pub. Date : 1996 Sep 6
PMID : 8703019
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. | Tyrosine | Janus kinase 2 | Rattus norvegicus |
| 2 | In this study, we examined the ability of insulin to stimulate JAK2 tyrosine phosphorylation in insulin-sensitive tissues of the intact rat using immunoprecipitation and immunoblotting. | Tyrosine | Janus kinase 2 | Rattus norvegicus |
| 3 | The results demonstrate that after an infusion of insulin, JAK2 is rapidly tyrosine phosphorylated (and the kinase is activated) in the liver, adipose tissue, skeletal muscle, heart, and isolated adipocytes. | Tyrosine | Janus kinase 2 | Rattus norvegicus |
| 4 | In two animal models of insulin resistance the regulation of JAK2 tyrosine phosphorylation after insulin infusion paralleled the phosphorylation of the insulin receptor and of IRS-1. | Tyrosine | Janus kinase 2 | Rattus norvegicus |
| 5 | In conclusion, our data indicate that after physiological stimulation by insulin in the intact animal, JAK2 associates with the insulin receptor and is tyrosine phosphorylated in insulin-sensitive tissues in a time- and dose-dependent fashion. | Tyrosine | Janus kinase 2 | Rattus norvegicus |